You are given two sentences. You have to find if there is entailment or agreement of the Hypothesis by the Premise. From the given pair of sentences, you should identify if there is enough information in the Premise to support the claim made in the Hypothesis. The Premise may not exactly be the same as Hypothesis. Your task is to return 'entails' if the premise supports hypothesis else return 'neutral'.

Let me give you an example: Premise: Lyme Disease is caused by a bacterium that's transmitted by tick bite, but many infected people don't remember a bite. 
 Hypothesis: Lyme disease is caused by bacteria.
The answer to this example can be: entails
Here is why: The premise sentence agrees with the hypothesis that Lyme Disease is a bacterium. The premise also gives additional information about Lyme disease. Therefore Premise entails Hypothesis.

OK. solve this:
Premise: The significance of these changes lies in the demonstration that they were associated with the release of calcium ion, which as a 'second messenger', was proposed in turn to activate systems that direct development of the early stages of the parasite (94). 
 Hypothesis: Calcium ion is an example of a second messenger.
Answer:
entails