Given the task definition and input, reply with output. You are given two sentences. You have to find if there is entailment or agreement of the Hypothesis by the Premise. From the given pair of sentences, you should identify if there is enough information in the Premise to support the claim made in the Hypothesis. The Premise may not exactly be the same as Hypothesis. Your task is to return 'entails' if the premise supports hypothesis else return 'neutral'.

Premise: Gating by internal Calcium Internal calcium is a second messenger (see ligand gating above) in many cell types, and thus channels gated by this ion can be characterized as ligand gated channels from the inside. 
 Hypothesis: Calcium ion is an example of a second messenger.
entails